Rapid NMDA receptor phosphorylation and oxidative stress precede striatal neurodegeneration after hypoxic ischemia in newborn piglets and are attenuated with hypothermia

Author:

Mueller‐Burke Dawn12,Koehler Raymond C.2,Martin Lee J.34

Affiliation:

1. School of Nursing, University of Maryland at BaltimoreBaltimoreMD21201United States

2. Department of Anesthesiology and Critical Care MedicineJohns Hopkins University School of MedicineBaltimoreMD21205United States

3. Department of PathologyJohns Hopkins University School of MedicineBaltimoreMD21205United States

4. Department of NeuroscienceJohns Hopkins University School of MedicineBaltimoreMD21205United States

Funder

National Institute of Neurological Disorders and Stroke

Publisher

Wiley

Subject

Developmental Biology,Developmental Neuroscience

Reference60 articles.

1. Hypothermia for 24 Hours After Asphyxic Cardiac Arrest in Piglets Provides Striatal Neuroprotection That Is Sustained 10 Days After Rewarming

2. Proton spectroscopy and diffusion imaging on the first day of life after perinatal asphyxia: preliminary report;Barkovich A.J.;Am. J. Neuroradiol.,2001

3. The double‐edged role of nitric oxide in brain function and superoxide‐mediated injury;Beckman J.S.;J. Dev. Physiol.,1991

4. Increased phosphorylation and redistribution of NMDA receptors between synaptic lipid rafts and post-synaptic densities following transient global ischemia in the rat brain

5. Hypoxia increases calcium flux through cortical neuron glutamate receptors via protein kinase C

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