Development of an orally bioavailable selective inhibitor of the menin-MLL
Author:
Publisher
Elsevier BV
Subject
Cell Biology,Genetics (clinical),Molecular Biology,Biochemistry
Reference5 articles.
1. Menin is necessary for long term maintenance of meningioma-1 driven leukemia;Libbrecht;Leukemia,2021
2. The menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML;Heikamp;Blood,2022
3. Pharmacologic inhibition of the menin-MLL interaction leads to transcriptional repression of PEG10 and blocks hepatocellular carcinoma;Kempinska;Mol Cancer Therapeut,2018
4. PKM2 drives hepatocellular carcinoma progression by inducing immunosuppressive microenvironment;Li;Front Immunol,2020
5. Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia;Grembecka;Nat Chem Biol,2012
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