The proximate carcinogen trans-3,4-dihydroxy-3,4-dihydro-dibenz[c,h]acridine is oxidized stereoselectively and regioselectively by cytochrome 1A1, epoxide hydrolase and hepatic microsomes from 3-methylcholanthrene-treated rats

Author:

Adams James D,Sayer Jane M,Chadha Anju,Shirai Naohiro,Lehr Roland E,Kumar Subodh,Jerina Donald M

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference35 articles.

1. Benzacridines and dibenzacridines: metabolism, mutagenicity and carcinogenicity;Lehr,1988

2. The bay region theory: a quantum mechanical approach to aromatic hydrocarbon induced carcinogenicity;Jerina,1977

3. Mutagenicity and tumorigenicity of enantiomers of the diasteriomeric bay region dibenz[c,h]acridine 3,4-diol-1,2-epoxides;Wood;Proc. Am. Assoc. Cancer Res.,1985

4. Metabolism of dibenz[c,h]acridine by rat liver microsomes and by cytochrome P450c with and without epoxide hydrolase;Thakker;Proc. Am. Assoc. Cancer Res.,1985

5. Separation and characterization of highly purified forms of liver microsomal cytochrome P450 from rats pretreated with polychlorinated biphenyl, phenobarbital and 3-methylcholanthrene;Ryan;J. Biol. Chem.,1979

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