A General Approach to Angucyclines: Synthesis of Hatomarubigin A, Rubiginone B2, Antibiotic X-1488E, 6-Hydroxytetrangulol, and Tetrangulol
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Reference25 articles.
1. For comprehensive reviews, see: (a) Krohn, K.; Rohr, J. Top. Curr. Chem. 1997, 188, 127–195.
2. (b) Rohr, J.; Thiericke, R. Nat. Prod. Rep. 1992, 9, 103–137.
3. For the structure elucidation of urdamycin A and for the introduction of the angucycline/angucyclinone terminology, see Drautz, H.; Zahner, H.; Rohr, J.; Zeeck, J. J. Antibiot. 1986, 39, 1657–1669.
4. For a recent contribution that describes the genetic modification of Streptomyces fradiae Tu2717, the urdamycin producer, and the resulting discovery of novel urdamycins in which glycosylation has been interrupted, see Kunzel, E.; Faust, B.; Oelkers, C.; Weissbach, U.; Bearden, D. W.; Weitnauer, G.; Westrich, L.; Bechthold, A.; Rohr, J. J. Am. Chem. Soc. 1999, 121, 11058–11062.
5. Naturally occurring quinones. Part XXVI. A synthesis of tetrangulol (1,8-dihydroxy-3-methylbenz[a]anthracene-7,12-quinone)
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