Author:
Ciuffreda Pierangela,Casati Silvana,Santaniello Enzo
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Reference24 articles.
1. (a) Cory, J. G.; Suhadolnik, R. J. Biochemistry 1965, 4, 1729–1732.
2. (b) Cory, J. G.; Suhadolnik, R. J. Biochemistry 1965, 4, 1733–1735.
3. Lipophilic, Acid-Stable, Adenosine Deaminase-Activated Anti-HIV Prodrugs for Central Nervous System Delivery. 2. 6-Halo- and 6-Alkoxy Prodrugs of 2'-.beta.-Fluoro-2',3'-dideoxyinosine
4. Lipase-catalyzed protection of the hydroxy groups of the nucleosides inosine and 2′-deoxyinosine: A new chemoenzymatic synthesis of the antiviral drug 2′,3′-dideoxyinosine
5. In a different synthetic approach, we started from inosine 2 and unsuccessfully tried to prepare the classical 2′,3′-O-(methoxymethylene) derivative that was needed for further elaboration. Due to insolubility of 2 in the reaction medium, poor yields of the required compound were obtained using trimethylorthoformate as reagent and solvent, whereas addition of DMSO or DMF improved the yields but complicated the work-up.
Cited by
28 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献