Practical stereocontrolled synthesis of 2-functionalized-methyl-1β-methylcarbapenems
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Reference9 articles.
1. Synthesis of 2-(heteroarylthiomethyl)-1.BETA.-methylcarbapenem via propargylation of 4-acetoxy-2-azetidinone with 3-methyl-1-tributylstannylallene.
2. The synthesis of 2-(functionalized methyl)-1.BETA.-methylcarbapenems.
3. Carbapenem and penem antibiotics. V. Carbapenem and penem antibiotics. VI. Synthesis and antibacterial activity of 2-heteroaromatic-thiomethyl and 2-carbamoyloxymethyl 1-methylcarbapenems.
4. A novel carbapenem antibiotic, SM-7338 structure-activity relationships.
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1. ChemInform Abstract: Practical, Stereocontrolled Synthesis of 2-Functionalized-methyl-1. beta.-methylcarbapenems.;ChemInform;2010-08-18
2. Process Development on (3S,4S)-[(R)-1‘-((tert-Butyldimethylsilyl)oxy)ethyl]-4-[(R)-1-carboxyethyl]-2-azetidinone: 1-β-Methylcarbapenem Key Intermediate;Organic Process Research & Development;2001-02-01
3. Synthesis and antibacterial activity of 2α-functionalized 1β-methylcarbapenems related to KR-21012;Bioorganic & Medicinal Chemistry Letters;2000-02
4. Synthesis and activity of 2-(sulfonamido)methyl-carbapenems: Discovery of a novel, anti-MRSA 1,8-naphthosultam pharmacophore;Bioorganic & Medicinal Chemistry Letters;1999-03
5. Preparation of crystallinep-nitrobenzyl 2-hydroxymethyl carbapenem as a key intermediate for the anti-MRS carbapenem L-786,392;Tetrahedron Letters;1999-01
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