1,3-Dipolar cycloaddition reactions of ester-stabilized azomethine ylides with acrolein: a one-pot regio- and stereoselective synthesis of N-substituted 4-formyl-5-vinyl proline carboxylates

Author:

Gu Yu Gui,Xu Yibo,Krueger A.Chris,Madigan Darold,Sham Hing L.

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference8 articles.

1. For reviews, see: (a) 1,3-Dipolar Cycloaddition Chemistry; Padwa, A., Ed.; Wiley-Interscience: New York, 1984; (b) Grigg, R. Chem. Soc. Rev. 1987, 16, 89; (c) Tsuge, O.; Kanemasa, S. In Advances in Heterocyclic Chemistry; Katritzky, A. R., Ed.; Academic Press: San Diego, 1989; Vol. 45, pp. 323–349.

2. Stereospecific Conversion of cis-trans Isomeric Aziridines to Open-Chain Azomethine Ylides

3. Simple Generation of Ester-Stabilized Azomethine Ylides from 2-Amino Esters and Carbonyl Compounds. Stereochemistry of Their Cycloadditions

4. For examples, see: (a) Flanagan, M. E.; Williams, R. M. J. Org. Chem. 1995, 60, 6791–6797; (b) Confalone, P. N.; Huie, E. M. J. Am. Chem. 1984, 106, 7175–7178; (c) Confalone, P. N.; Earl, R. A. Tetrahedron Lett. 1986, 27, 2695–2698.

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