Utilization of the chiral synthon, methyl 3-O-benzyl-2,4,6-trideoxy-6-iodo-α-D--hexopyranoside in the synthesis of a potent HMG-CoA reductase inhibitor-Reference-Cited by-同舟云学术

Utilization of the chiral synthon, methyl 3-O-benzyl-2,4,6-trideoxy-6-iodo-α-D--hexopyranoside in the synthesis of a potent HMG-CoA reductase inhibitor

Published:1985-01 Issue:25 Volume:26 Page:2947-2950
ISSN:0040-4039
Container-title:Tetrahedron Letters
language:en
Short-container-title:Tetrahedron Letters

Author:

Prugh John D.,Rooney C.Stanley,Deana Albert A.,Ramjit Harri G.

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference12 articles.

1. A.K. Willard, F.C. Novello, W.F. Hoffman and E.J. Cragoe, U.S. Patent, 4,375,475 (1983).

2. Methyl 3-0-benzyl-2,4,6-trideoxy-6-iodo-α-d--hexopyranoside, a chiral synthon for the synthesis of inhibitors of HMG-CoA reductase

3. Mevinic acids and analogues: preparation of a key chiral intermediate

4. Synthesis of 2,4-dideoxy-d-erythro-hexopyranose. An intermediate for synthesis of the lactone moiety of inhibitors of hydroxymethylglutaryl-coenzyme A reductase

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