‘meso-Selective’ functionalisation of N-benzyl-α-methylbenzylamine derivatives by α-lithiation and alkylation

Author:

Bragg Ryan A,Clayden Jonathan,Menet Christel J

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference31 articles.

1. Recent advances in asymmetric synthesis using chiral lithium amide bases

2. Enantioselective synthesis of macrocyclic propargylic alcohols by [2,3] Wittig ring contraction. Synthesis of (+)-aristolactone and cembranoid precursors

3. Stereochemistry of the Decomposition of N-Nitroso- and N-Amino-α,α'-dimethyldibenzylamine1

4. The meso amine 2 has principally been used for NMR studies of amide conformation and stereodynamics. See (a) Langgård, M.; Sandström, J. J. Chem. Soc., Perkin Trans. 2 1996, 435; (b) Bragg, R. A.; Clayden, J. Org. Lett. 2000, 2, 3351; (c) Bragg, R. A.; Clayden, J.; Morris, G. A.; Pink, J. H. Chem. Eur. J., in press.

5. Stereospecific formation of tetrasubstituted centres from trisubstituted centres during dearomatising anionic cyclisations

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