Nickel catalyzed cross-coupling of modified alkyl and alkenyl Grignard reagents with aryl- and heteroaryl nitriles: activation of the CCN bond

Author:

Miller Joseph A,Dankwardt John W

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference11 articles.

1. For general references, see: (a) Negishi, E.-i.; Liu, F. In Metal-Catalyzed Cross-Coupling Reactions; Diederich, F.; Stang, P. J., Eds.; Wiley-VCH: Weinheim, 1998; pp. 1–48;

2. (b) Farina, V. In Comprehensive Organometallic Chemistry II; Abel, E. W.; Stone, F. G. A.; Wilkinson, G.; Hegedus, L. S., Eds.; Pergamon: Oxford, 1995; Vol. 3.4, pp. 161–240.

3. (c) For a review on nickel catalyzed cross-coupling of Grignard reagents and aryl halides, see: Kumada, M. Pure Appl. Chem. 1980, 52, 669.

4. For an example of CF bond activation of aryl fluorides, see: Bohm, V. P. W.; Gstottmayer, C. W. K.; Weskamp, T.; Herrmann, W. A. Angew. Chem., Int. Ed. Engl. 2001, 40, 3387.

5. For an example using a carbamate leaving group, see: Sengupta, S.; Leite, M.; Rasland, D. S.; Quesnelle, C.; Snieckus, V. J. Org. Chem. 1992, 57, 4066.

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