New synthetic routes to 9(0)-methanoprostacyclin. A highly stable and biologically potent analog of prostacyclin
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Reference13 articles.
1. Intramolecular sulfenyl bromide addition promising a new synthetic route to 9(O)-thiaprostacyclin
2. Synthesis of 9(O)-thiaprostacyclin
3. Vasodilation produced by prostacyclin (PGI2) and 9(0)-thiaprostacyclin (PGI2-S) in the caninen femoral circulation
4. 6,9-Thiaprostacyclin. A stable and biologically potent analog of prostacyclin (PGI2)
5. Organoselenium-induced ring closures. Stereoselective synthesis of cyclic .alpha.,.beta.-unsaturated sulfoxides, sulfones, and sulfides and synthesis of 6,9-sulfoxa-5(E)- and -5(Z)-prostacyclin, 6,9-sulfo-5(E)- and -5(Z)-prostacyclin, 6,9-sulfo-6.alpha.- and -6.beta.-4(E)-isoprostacyclin, and 6,9-thiaprostacyclin
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