Separation of Cdc25 dual specificity phosphatase inhibition and DNA cleaving activities in a focused library of analogs of the antitumor antibiotic Dnacin-Reference-Cited by-同舟云学术

Separation of Cdc25 dual specificity phosphatase inhibition and DNA cleaving activities in a focused library of analogs of the antitumor antibiotic Dnacin

Published:2002-08 Issue:32 Volume:58 Page:6367-6372
ISSN:0040-4020
Container-title:Tetrahedron
language:en
Short-container-title:Tetrahedron

Author:

Wipf Peter,Hopkins Corey R,Phillips Eleanor O,Lazo John S

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference61 articles.

1. Natural Products Are Biologically Validated Starting Points in Structural Space for Compound Library Development: Solid-Phase Synthesis of Dysidiolide-Derived Phosphatase Inhibitors This research was supported by the Fonds der Chemischen Industrie and the Bayer AG.

2. Identification of a Potent and Selective Pharmacophore for Cdc25 Dual Specificity Phosphatase Inhibitors.

3. Discovery and Biological Evaluation of a New Family of Potent Inhibitors of the Dual Specificity Protein Phosphatase Cdc25

4. Sulfonylated aminothiazoles as new small molecule inhibitors of protein phosphatases

5. Synthesis of a Tetronic Acid Library Focused on Inhibitors of Tyrosine and Dual-Specificity Protein Phosphatases and Its Evaluation Regarding VHR and Cdc25B Inhibition

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