Efficient synthesis of purine analogues: an FeCl3–SiO2-promoted cyclization reaction of 4,5-diaminopyrimidines with aldehydes leading to 6,8,9-trisubstituted purines

Author:

Dang Qun,Brown Brian S,Erion Mark D

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference11 articles.

1. Appleman, J. R.; Erion, M. D. Exp. Opin. Invest. Drugs 1998, 7, 225. Jacobson, K. A.; Jarvis, M. F., Eds. Purinergic Approaches in Experimental Therapeutics; John Wiley & Sons: New York, 1997. Chu, C. K.; Baker, D. C., Eds. Nucleosides and Nucleotides as Antitumor and Antiviral Agents; Plenum: New York, 1993. Bonnet, P. A.; Robins, R. K. J. Med. Chem. 1993, 36, 635. Erion, M. D. Annu. Rep. Med. Chem. 1993, 28, 295. Huryn, D. M.; Okabe, M. Chem. Rev. 1992, 92, 1745.

2. Dang, Q.; Brown, B. S.; Erion, M. D. J. Org. Chem. 1996, 61, 5204. Dang, Q.; Liu, Y.; Erion, M. D. J. Am. Chem. Soc. 1999, 121, 5833.

3. Lister, J. H., Ed. The Purines; John Wiley & Sons: New York, 1996; Vol. 54 (Suppl. I), pp. 21–60.

4. Hocek, M.; Holy, A.; Votruba, I.; Dvorakova, H. J. Med. Chem., 2000, 43, 1145, and references cited therein.

5. Giner-Sorolla, A.; Segarra, J. T.; Brooks, M. H. J. Med. Chem. 1978, 21, 344.

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