The synthesis of (4R-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate, a key intermediate for the preparation of CI-981, a highly potent, tissue selective inhibitor of HMG-CoA reductase-Reference-Cited by-同舟云学术

The synthesis of (4R-cis)-1,1-dimethylethyl 6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate, a key intermediate for the preparation of CI-981, a highly potent, tissue selective inhibitor of HMG-CoA reductase

Published:1992-04 Issue:17 Volume:33 Page:2279-2282
ISSN:0040-4039
Container-title:Tetrahedron Letters
language:en
Short-container-title:Tetrahedron Letters

Author:

Brower Philip L.,Butler Donald E.,Deering Carl F.,Le Tung V.,Millar Alan,Nanninga Thomas N.,Roth Bruce D.

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference33 articles.

1. HMG-CoA Reductase Inhibitors for Treatment of Hypercholesterolemia

2. Pharmacology and mechanism of action of the new HMG-CoA reductase inhibitors

3. Design and Synthesis of 4-Ozxquinolin-2-yl-6-heptenoic Acid Derivatives as HMG-CoA Reductase Inhibitors

4. Inhibitors of cholesterol biosynthesis. 1. trans-6-(2-Pyrrol-1-ylethyl)-4-hydroxypyran-2-ones, a novel series of HMG-CoA reductase inhibitors. 1. Effects of structural modifications at the 2- and 5-positions of the pyrrole nucleus

5. Inhibitors of cholesterol biosynthesis. 2. 1,3,5-Trisubstituted [2-(tetrahydro-4-hydroxy-2-oxopyran-6-yl)ethyl]pyrazoles

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