First synthesis of (1R,2R,3S,9S,9aR)-1,2,3,9-tetrahydroxy-quinolizidine, a novel isosteric homologue of the glucosidase inhibitor castanospermine
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Reference20 articles.
1. Castanospermine, A 1,6,7,8-tetrahydroxyoctahydroindolizine alkaloid, from seeds of Castanospermum australe
2. Castanospermine, a tetrahydroxylated alkaloid that inhibits β-glucosidase and β-glucocerebrosidase
3. Castanospermine inhibits glucosidase I and glycoprotein secretion in human hepatoma cells
4. Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase
5. CASTANOSPERMINE AND OTHER PLANT ALKALOID INHIBITORS OF GLUCOSIDASE ACTIVITY BLOCK THE GROWTH OF HIV
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1. Concise synthesis of bicyclic iminosugars via reductive functionalization of sugar-derived lactams and subsequent RCM reaction;Organic & Biomolecular Chemistry;2021
2. Polyhydroxylated Quinolizidine Iminosugars as Nanomolar Selective Inhibitors of α-Glucosidases;The Journal of Organic Chemistry;2017-08-28
3. Asymmetric Synthesis of Pyrrolizidines, Indolizidines and Quinolizidines via a Double Reductive Cyclisation Protocol;Synlett;2017-08-08
4. Chemoenzymatic synthesis, structural study and biological activity of novel indolizidine and quinolizidine iminocyclitols;Organic & Biomolecular Chemistry;2012
5. An efficient approach to new dihydroxyquinolizidines;Tetrahedron: Asymmetry;2010-08
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