A short, efficient total synthesis of (±) acivicin and (±) bromo-acivicin
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Reference13 articles.
1. Total synthesis of .alpha.-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125), an antitumor antibiotic
2. Total synthesis of antitumor agent AT-125, (.alpha.S,5S)-.alpha.-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid
3. Stereospecific total syntheses of the natural antitumor agent, (.alpha.S, 5S)-.alpha.-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, and its unnatural C-5 epimer
4. Cyanogen chloride N-oxide cycloadditions. A simple, short route to AT-125.
5. Synthesis of analogues of the antitumor antibiotic at-125 (acivicin)
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