Intra- and intermolecular nucleophilic phosphorous - sulfur bond cleavage. The reaction of fluoride ion with O-aryl-O, S-dialkylphosphorothioates, & the degradation of phosphorothioate linkage in di-ribonucleotides by the vicinal 2′-hydroxyl group.-Reference-Cited by-同舟云学术

Intra- and intermolecular nucleophilic phosphorous - sulfur bond cleavage. The reaction of fluoride ion with O-aryl-O, S-dialkylphosphorothioates, & the degradation of phosphorothioate linkage in di-ribonucleotides by the vicinal 2′-hydroxyl group.

Published:1989-01 Issue:23 Volume:45 Page:7523-7544
ISSN:0040-4020
Container-title:Tetrahedron
language:en
Short-container-title:Tetrahedron

Author:

Sund Christian,Chattopadhyaya Jyoti

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference45 articles.

1. Inhibition of human immunodeficiency virus replication by antisense oligodeoxynucleotides.

2. Antiviral effect of an oligo(nucleoside methylphosphonate) complementary to the splice junction of herpes simplex virus type 1 immediate early pre-mRNAs 4 and 5.

3. Phosphorothioate analogs of oligodeoxynucleotides: inhibitors of replication and cytopathic effects of human immunodeficiency virus.

4. Specific antiviral activity of a poly(L-lysine)-conjugated oligodeoxyribonucleotide sequence complementary to vesicular stomatitis virus N protein mRNA initiation site.

5. Methylphosphonates as probes of protein-nucleic acid interactions

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3. Double Sugar and Phosphate Backbone-Constrained Nucleotides: Synthesis, Structure, Stability, and Their Incorporation into Oligodeoxynucleotides;The Journal of Organic Chemistry;2009-04-06

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5. Fluoride-ion-mediated Hydrolysis of Phosphoric Acid Esters, Amides, and Phosphorous Acid Esters Leading to Phosphorofluoridic, Phosphoramide Fluoridic, and Phosphonic Acid Monoester Salts;Chemistry Letters;2008-12-05