An enantioselective approach to carbapenem antibiotics: formal synthesis of (+)-thienamycin
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Reference19 articles.
1. Preparation of primary amines and 2-azetidinones via N-(trimethylsilyl)imines
2. N-Trimethylsilylimines: applications to the syntheses of .beta.-lactams
3. A FACILE ENTRY TO 3-(1-HYDROXYETHYL)-2-AZETIDINONES FROM METHYL (R)-3-HYDROXYBUTANOATE BASED ON THE ESTER ENOLATE-ALDIMINE CONDENSATION
4. Stereocontrolled total synthesis of the chiral building block (3S,4R)-3- [(R)-1-hydroxyethyl]-4-acetyloxy-azetidin-2-one: a useful synthon for the synthesis of (+)-thienamycin, carbapenems and penems.
5. Reaction of silyl ketene acetals with N-trimethylsilyl imines: a route to N-unsubstituted azetidin-2-ones
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