Total synthesis of biologically active metabolites of arachidonic acid. The two 8-hydroxy-11,12(S,S)-epoxyeicosa-5,14(Z),9(E)-trienoic acids.
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Reference8 articles.
1. Total synthesis of 12-()-10-hydroxy--11,12-epoxyeicosa-5,9,14-()-trienoic acids, metabolites of arachidonic acid in mammalian blood platelets
2. A new reaction of unsaturated fatty acid hydroperoxides: Formation of 11-hydroxy-12,13-epoxy-9-octadecenoic acid from 13-hydroperoxy-9,11-octadecadienoic acid
3. New synthetic routes to leukotrienes and other arachidonate derived epoxy eicosatetraenoic acids (epete's). Exclusion of the hydroxy epoxide pathway for leukotriene biosynthesis
4. Stereochemistry of the lipoxygenase-catalyzed allylic hydroperoxide→oxiranylcarbinol rearrangements
5. Arachidonic acid epoxides. Isolation and structure of two hydroxy epoxide intermediates in the formation of 8,11,12- and 10,11,12-trihydroxyeicosatrienoic acids.
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