Sequential cyclizations of 2-isothiocyanatobenzonitrile and 2-isocyanatobenzonitrile with α-aminoketones
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Reference14 articles.
1. For reviews of domino and sequential reactions, see: (a) Tietze, L. F.; Beifuss, U., Angew. Chem. 1993, 105, 137; Angew. Chem., Int. Ed. Engl. 1993, 32, 131; (b) Tietze, L. F., Chem. Rev. 1996, 96, 115.
2. For reviews of work from our laboratory, see: (a) Langer, P. Chem. Eur. J. 2001, 7, 3858; (b) Langer, P.; Döring, M. Eur. J. Org. Chem. 2002, 221; (c) Langer, P. Synthesis 2002, 441.
3. For reactions of 2-isothiocyanatobenzonitrile and 2-isocyanatobenzonitrile, see: (a) Calestani, G.; Capella, L.; Leardini, R.; Minozzi, M.; Nanni, D.; Papa, R.; Romina, R.; Zanardi, G. Tetrahedron 2001, 57, 7221; (b) Pfeiffer, W.-D.; Hetzheim, A.; Pazdera, P.; Bodtke, A.; Mücke, J. J. Het. Chem. 1999, 36, 1327; (c) Besson, T.; Guillard, J.; Rees, C. W.; Therisod, M. J. Chem. Soc., Chem. Commun. 1997, 881; (d) Leardini, R.; Nanni, D.; Pareschi, P.; Tundo, A.; Zanardi, G. J. Org. Chem. 1997, 62, 8394; (e) Pfeiffer, W. D.; Pazdera, P.; Hetzheim, A.; Muecke, J. Pharmazie 1995, 50, 21; (f) Pavia, M. R.; Lobbestael, S. J.; Taylor, C. P.; Hershenson, F. M.; Miskell, D. L. J. Med. Chem. 1990, 33, 854; for cyclizations of 1a and 1b with carboxylic hydrazides, see: (g) Francis, J. E.; Cash, W. D.; Psychoyos, S.; Ghai, G.; Wenk, P.; Friedmann, R. C.; Atkins, C.; Warren, V.; Furness, P.; Hyun, J. L.; Stone, G. A.; Desai, M.; Williams, M. J. Med. Chem. 1988, 31, 1014; see also: (h) Blank, J.; Kandt, M.; Pfeiffer, W.-D.; Hetzheim, A.; Langer, P. Eur. J. Org. Chem. 2003, 182.
4. Synthesis and benzodiazepine binding activity of a series of novel [1,2,4]triazolo[1,5-c]quinazolin-5(6H)-ones
5. Identification of N-Hydroxamic Acid and N-Hydroxyimide Compounds that Inhibit the Influenza Virus Polymerase
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