Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting

Author:

Srivastava Shivani,Salter Alexander I.,Liggitt Denny,Yechan-Gunja Sushma,Sarvothama Megha,Cooper Kirsten,Smythe Kimberly S.,Dudakov Jarrod A.,Pierce Robert H.,Rader Christoph,Riddell Stanley R.

Funder

National Institutes of Health

Cancer Center

Cancer Research Institute

FHCRC

Publisher

Elsevier BV

Subject

Cancer Research,Cell Biology,Oncology

Reference39 articles.

1. Regulation of hematopoietic stem cells by bone marrow stromal cells;Anthony;Trends Immunol.,2014

2. Analysis of ROR1 protein expression in human cancer and normal tissues;Balakrishnan;Clin. Cancer Res.,2017

3. Safety of targeting ROR1 in primates with chimeric antigen receptor-modified T cells;Berger;Cancer Immunol. Res.,2015

4. Bourquin, C., Castoldi, R., Endres, S., Klein, C., Kobold, S., Niederfellner, G., Sustmann, C., 2015. Bispecific antibody molecules with antigen-transfected t-cells and their use in medicine. US patent application publication 20150010567A1, filed January 24, 2013, and published January 8, 2015.

5. Toxicities of chimeric antigen receptor T cells: recognition and management;Brudno;Blood,2016

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