Mechanisms of Sensitivity and Resistance to CDK4/6 Inhibition

Author:

Álvarez-Fernández Mónica,Malumbres Marcos

Funder

Fundación Científica Asociación Española Contra el Cáncer

Ministerio de Ciencia e Innovación

Dirección General de Universidades e Investigación

Publisher

Elsevier BV

Subject

Cancer Research,Cell Biology,Oncology

Reference140 articles.

1. Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma;AbuHammad;Proc. Natl. Acad. Sci. U S A,2019

2. Cdc2-cyclin E complexes regulate the G1/S phase transition;Aleem;Nat. Cell Biol.,2005

3. A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells;Anders;Cancer Cell,2011

4. The history and future of targeting cyclin-dependent kinases in cancer therapy;Asghar;Nat. Rev. Drug Discov.,2015

5. Behenna, D.C., Chen, P., Freeman-Cook, K.D., Hoffman, R.L., Jalaie, M., Nagata, A., Nair, S.K., Ninkovic, S., Ornelas, M.A., Palmer, C.L., and Rui, E.Y. (2018). CDK2/4/6 inhibitors. USA Patent Application Publication US 2018/0044344 A1.

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