Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy-Reference-Cited by-同舟云学术

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Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy

Published:2019-06 Issue:6 Volume:35 Page:851-867.e7
ISSN:1535-6108
Container-title:Cancer Cell
language:en
Short-container-title:Cancer Cell

Author:

Fang Yong,McGrail Daniel J.,Sun Chaoyang,Labrie Marilyne,Chen Xiaohua,Zhang Dong,Ju Zhenlin,Vellano Christopher P.,Lu Yiling,Li Yongsheng,Jeong Kang Jin,Ding Zhiyong,Liang Jiyong,Wang Steven W.,Dai Hui,Lee Sanghoon,Sahni Nidhi,Mercado-Uribe Imelda,Kim Tae-beom,Chen Ken,Lin Shiaw-Yih,Peng Guang,Westin Shannon N.,Liu Jinsong,O'Connor Mark J.,Yap Timothy A.,Mills Gordon B.

Funder

Adelson Research Foundation

NIH

Komen Foundation

Breast Cancer Research Foundation

Ovarian Cancer Research Foundation

CPRIT

CCSG

Susan G. Komen grant

AstraZeneca

Immunomet

Pfizer

Nanostring

Tesaro

Vertex

ArQule

Bayer

Clovis Oncology

Cotinga

Novartis

Roche

Publisher

Elsevier BV

Subject

Cancer Research,Cell Biology,Oncology

Reference62 articles.

1. A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair;Ashworth;J. Clin. Oncol.,2008

2. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints;Bartkova;Nature,2006

3. Cyclin-dependent kinase suppression by WEE1 kinase protects the genome through control of replication initiation and nucleotide consumption;Beck;Mol. Cell. Biol.,2012

4. Replication stress: getting back on track;Berti;Nat. Struct. Mol. Biol.,2016

5. Maintaining genome stability at the replication fork;Branzei;Nat. Rev. Mol. Cell Biol.,2010

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