Botulinum neurotoxin serotypes A and B preparations have different safety margins in preclinical models of muscle weakening efficacy and systemic safety

Author:

Roger Aoki K

Publisher

Elsevier BV

Subject

Toxicology

Reference31 articles.

1. Preclinical update on BOTOX® (botulinum toxin type A)-purified neurotoxin complex relative to other botulinum neurotoxin preparations;Aoki;Eur. J. Neurol.,1999

2. A comparison of the safety margins of botulinum neurotoxin serotypes A, B, and F in mice;Aoki;Toxicon,2001

3. Arezzo, J.C., Litwak, M.S., Caputo, F.A., Shopp, G.M., Meyer, K.E., 2000. Distant effects of localized injection of BoNT-B vs BoNT-A: implications to toxin therapy. Poster Presented at the 30th Annual Meeting of the Society for Neuroscience, November 4–9, 2000; New Orleans, LA.

4. Proteolysis of SNAP-25 by types E and A botulinum neurotoxins;Binz;J. Biol. Chem.,1994

5. Interaction of 125-I labeled botulinum neurotoxins with nerve terminals. I. Ultrastructural autoradiographic localization and quantitation of distinct membrance acceptors for types A and B on motor nerves;Black;J. Cell Biol.,1986

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