Suitability of histopathology as an additional endpoint to the Isolated Chicken Eye Test for classification of non-extreme pH detergent and cleaning products

Author:

Cazelle Elodie,Eskes Chantra,Hermann MartinaORCID,Jones Penny,McNamee PaulineORCID,Prinsen Menk,Taylor Hannah,Wijnands Marcel V.W.

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference21 articles.

1. EC, 1999. Directive 1999/45/EC of the European Parliament and of the Council of 31 May 1999 concerning the approximation of laws, regulations and administrative provisions of the Member States relating to the classification, packaging and labelling of dangerous preparations. Official Journal of the European Communities L 200, p. 1–68.

2. EC, 2008. Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on Classification, Labelling and Packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006. Official Journal of the European Union L353, pp. 1–1355.

3. ESAC, 2009. Statement on the use of existing Low Volume Eye Test (LVET) data for Weight-of-Evidence decisions on classification and labelling of cleaning products and their main ingredients. (accessed 19.06.13).

4. Human and rabbit eye responses to chemical insult;Freeberg;Fundam. Appl. Toxicol.,1986

5. Dose-response studies with chemical irritants in the albino rabbit eye as basis for selecting optimum testing conditions for predicting hazard to the human eye;Griffith;Toxicol. Appl. Pharmacol.,1980

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