Identification of critical formulation and processing variables for metoprolol tartrate extended-release (ER) matrix tablets1This manuscript represents the personal opinions of the authors and does not necessarily represent the views or policies of the FDA.1

Author:

Rekhi Gurvinder Singh,Nellore Ranjani V,Hussain Ajaz S,Tillman Lloyd G,Malinowski Henry J,Augsburger Larry L

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference27 articles.

1. Policy and Procedure Guide #22-90: `Interim Policy on Exception to Batch-size for Non-Antibiotic, Solid Oral Dosage Form Drug Products Supporting Proposed ANDA's' Guidance (FDA, CDER, Office of Generic Drugs (OGD), Rockville, MD, 13 September 1990).

2. Workshop report: scaleup of immediate release oral solid dosage forms;Skelly;Pharm. Res.,1993

3. An approach toward establishing a scientific foundation for interpreting regulations and workshop reports on scale-up and post-approval changes;Augsburger;Pharm. Res.,1994

4. FDA, Guidance for industry—immediate release solid oral dosage forms/scale-up and post approval changes: chemistry, manufacturing, and controls. In Vitro Dissolution Testing and In Vivo Bioequivalence Documentation, Guidance effective November 30, 1995.

5. FDA, Guidance for industry—modified release solid oral dosage forms/Scale-up and post approval changes: chemistry, manufacturing, and controls. In Vitro Dissolution Testing and In Vivo Bioequivalence Documentation, Guidance effective October 6, 1997.

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