Neuraminidase characterisation reveals very low levels of antiviral resistance and the presence of mutations associated with reduced antibody effectiveness in the Irish influenza 2018/2019 season

Author:

Brehony CarinaORCID,Dunford Linda,Bennett Charlene,O’Donnell Joan,Domegan Lisa,McNamara Eleanor,De Gascun Cillian F.

Funder

National Virus Reference Laboratory

Publisher

Elsevier BV

Subject

Infectious Diseases,Virology

Reference22 articles.

1. Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors and status of novel antivirals, 2016–2017;Lackenby;Antiviral Res.,2018

2. Low frequency of reduced neuraminidase inhibitor susceptibility in twelve EU/EEA countries, 2008-2018;Broberg;Poster Presented at European Scientific Conference on Applied Infectious Disease Epidemiology (ESCAIDE) 2019,2019

3. Annual Epidemiological Report: Influenza and Other Seasonal Respiratory Viruses in Ireland, 2018/2019;HPSC,2019

4. The neuraminidase of A(H3N2) influenza viruses circulating since 2016 is antigenically distinct from the A/Hong Kong/4801/2014 vaccine strain;Wan;Nat. Microbiol.,2019

5. Antigenic drift of the influenza a(H1N1)pdm09 virus neuraminidase results in reduced effectiveness of A/California/7/2009 (H1N1pdm09)-Specific antibodies;Gao;MBio,2019

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