A randomized, blind, parallel controlled phase I clinical trial to evaluate the safety and preliminary immunogenicity of 23-valent pneumococcal polysaccharide vaccine in healthy people aged 2 years and older

Author:

Zhang Yuhui,Wang Yanxia,Li Guangfu,Zhao Xue,Wang Kai,Jia Chunyu,Yang Yongli,Huang Lili,Tan Jiebing,Chen Xiaofen,Leng Wenna,Xie Zhiqiang,Zhang Wei,Zong Juan,Chen Kang,Li Qin,Jia Xiaocan,Zhao Dongyang,An Youcai,Zhang Yaodong

Funder

National Institutes for Food and Drug Control

Publisher

Elsevier BV

Reference33 articles.

1. Moberley SA, Holden J, Tatham DP, Andrews RM. Vaccines for preventing pneumococc-al infection in adults. Cochrane Database Syst Rev. 2008 Jan 23;(1):CD000422. doi: 10.1002/14651858.CD000422.pub2. Update in: Cochrane Database Syst Rev. 2013;1:CD000422. PMID: 18253977.

2. The remaining challenges of pne-umococcal disease in adults;Ludwig;Eur Respir Rev,2012

3. 23-valent pneumococcal polysaccharide vaccine: WHO position paper;World Health Organization;Wkly Epidemiol Rec,2008

4. Dion CF, Ashurst JV. Streptococcus pneumoniae. 2022 Aug 8. In: StatPearls [Internet]. T-reasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 29261971.

5. Understanding the burden of pneumococcal dise-ase in adults;Blasi;Clin Microbiol Infect,2012

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