A multi-epitope DNA vaccine co-administered with monophosphoryl lipid A adjuvant provides protection against tick transmitted Ehrlichia ruminantium in sheep

Author:

Tshilwane S.I.ORCID,Thema N.,Steyn H.C.,van Kleef M.,Pretorius A.

Funder

NRF

THRIP

RMRDT

Publisher

Elsevier BV

Subject

Infectious Diseases,Public Health, Environmental and Occupational Health,General Veterinary,General Immunology and Microbiology,Molecular Medicine

Reference49 articles.

1. Trends in the control of heartwater;Allsopp;Onderstepoort J Vet Res,2009

2. Immune responses to Cowdria ruminantium infections;Totté;Parasitol Today,1999

3. Ehrlichia ruminantium antigens and peptides induce cytotoxic T cell responses in vitro;Thema;Vet Immunol Immunopathol,2019

4. Identification and characterisation of conserved epitopes of E. ruminantium that activate Th1 CD4+ T cells: Towards the development of a multiepitope vaccine;Thema;Mol Immunol,2019

5. Immunogenicity of multiepitope DNA and peptide vaccine candidates based on core, E2, NS3 and NS5B HCV epitopes in BALB/c mice;Sabet;Hepat Mon,2014

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