Antibody dependent cell cytotoxicity is maintained by the unmutated common ancestor of 6F5, a Gp41 conformational epitope targeting antibody that utilizes heavy chain VH1-2-Reference-Cited by-同舟云学术

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Antibody dependent cell cytotoxicity is maintained by the unmutated common ancestor of 6F5, a Gp41 conformational epitope targeting antibody that utilizes heavy chain VH1-2

Published:2022-07 Issue:31 Volume:40 Page:4174-4181
ISSN:0264-410X
Container-title:Vaccine
language:en
Short-container-title:Vaccine

Author:

Wrotniak Brian H.^ORCID,Garrett Meghan^ORCID,Baron Sarah,Sojar Hakimuddin,Shon Alyssa,Asiago-Reddy Elizabeth^ORCID,Yager Jessica,Kalams Spyros,Croix Michael,Hicar Mark D.^ORCID

Funder

National Institute on Aging

University of Washington

National Heart, Lung, and Blood Institute

Eunice Kennedy Shriver National Institute of Child Health and Human Development

National Cancer Institute

National Institute of General Medical Sciences

National Institute on Drug Abuse

National Institute of Diabetes and Digestive and Kidney Diseases

National Institutes of Health

National Institute of Mental Health

National Institute of Allergy and Infectious Diseases

Publisher

Elsevier BV

Subject

Infectious Diseases,Public Health, Environmental and Occupational Health,General Veterinary,General Immunology and Microbiology,Molecular Medicine

Reference37 articles.

1. Hicar MD, Chen X, Sulli C, Barnes T, Goodman J, Sojar H, et al. Human antibodies that recognize novel immunodominant quaternary epitopes on the HIV-1 Env protein. PLoS One. 2016;11:e0158861.

2. Low frequency of broadly neutralizing HIV antibodies during chronic infection even in quaternary epitope targeting antibodies containing large numbers of somatic mutations;Hicar;Mol Immunol,2016

3. Monoclonal antibody 2C6 targets a cross-clade conformational epitope in gp41 with highly active antibody-dependent cell cytotoxicity;Sojar;J Virol,2019

4. Immune-correlates analysis of an HIV-1 vaccine efficacy trial;Haynes;N Engl J Med,2012

5. Fc receptor but not complement binding is important in antibody protection against HIV;Hessell;Nature,2007

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Identification of a mimotope of a complex gp41 Human Immunodeficiency VIrus epitope related to a non-structural protein ofHepaciviruspreviously implicated in Kawasaki disease;2024-06-28

2. Functional diversification of innate and inflammatory immune responses mediated by antibody fragment crystallizable activities against SARS-CoV-2;iScience;2024-05

3. Identification of Anti-gp41 Monoclonal Antibodies That Effectively Target Cytotoxic Immunoconjugates to Cells Infected with Human Immunodeficiency Virus, Type 1;Vaccines;2023-04-12

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