Base editing of key residues in the BCL11A-XL-specific zinc finger domains derepresses fetal globin expression-Reference-Cited by-同舟云学术

Base editing of key residues in the BCL11A-XL-specific zinc finger domains derepresses fetal globin expression

Published:2024-03 Issue:3 Volume:32 Page:663-677
ISSN:1525-0016
Container-title:Molecular Therapy
language:en
Short-container-title:Molecular Therapy

Author:

Rajendiran Vignesh,Devaraju Nivedhitha,Haddad Mahdi,Ravi Nithin Sam,Panigrahi Lokesh,Paul Joshua,Gopalakrishnan Chandrasekar,Wyman Stacia,Ariudainambi Keerthiga,Mahalingam Gokulnath,Periyasami Yogapriya,Prasad Kirti,George Anila,Sukumaran Dhiyaneshwaran,Gopinathan Sandhiya,Pai Aswin Anand,Nakamura Yukio,Balasubramanian Poonkuzhali,Ramalingam Rajasekaran,Thangavel Saravanabhavan,Velayudhan Shaji R.,Corn Jacob E.,Mackay Joel P.,Marepally Srujan,Srivastava Alok,Crossley Merlin,Mohankumar Kumarasamypet M.^ORCID

Funder

Wellcome Trust DBT India Alliance

Australian Medical Council

India Ministry of Science & Technology Department of Biotechnology

Indian Council of Medical Research

Science and Engineering Research Board

Publisher

Elsevier BV

Reference47 articles.

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3. Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A;Sankaran;Science,2008

4. Transcriptional silencing of γ-globin by BCL11A involves long-range interactions and cooperation with SOX6;Xu;Genes Dev.,2010

5. Post-Transcriptional Genetic Silencing of BCL11A to Treat Sickle Cell Disease;Esrick;N. Engl. J. Med.,2021