Eliminating HIV-1 Packaging Sequences from Lentiviral Vector Proviruses Enhances Safety and Expedites Gene Transfer for Gene Therapy

Author:

Vink Conrad A.,Counsell John R.,Perocheau Dany P.,Karda Rajvinder,Buckley Suzanne M.K.,Brugman Martijn H.,Galla Melanie,Schambach Axel,McKay Tristan R.,Waddington Simon N.,Howe Steven J.

Funder

BBSRC Follow-On Fund and MRC Confidence in Concept grant

German Research Council

NC3Rs

BBSRC New Investigator Award

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology,Genetics,Molecular Biology,Molecular Medicine

Reference66 articles.

1. Design of a retrovirus-derived vector for expression and transduction of exogenous genes in mammalian cells;Perkins;Mol. Cell. Biol.,1983

2. Use of a HIV-1 retroviral vector system for gene transfer into human cells;Heisig;Haematol. Blood Transfus.,1989

3. Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo;Zufferey;Nat. Biotechnol.,1997

4. A third-generation lentivirus vector with a conditional packaging system;Dull;J. Virol.,1998

5. Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery;Zufferey;J. Virol.,1998

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