A New Role for the Mitochondrial Pro-apoptotic Protein SMAC/Diablo in Phospholipid Synthesis Associated with Tumorigenesis

Author:

Paul Avijit,Krelin Yakov,Arif Tasleem,Jeger Rina,Shoshan-Barmatz Varda

Funder

Israel Science Foundation

Phil and Sima Needleman

Yafa and Ezra Yerucham

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology,Genetics,Molecular Biology,Molecular Medicine

Reference57 articles.

1. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins;Verhagen;Cell,2000

2. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition;Du;Cell,2000

3. TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO;Deng;Genes Dev.,2002

4. Caspases, IAPs and Smac/DIABLO: mechanisms from structural biology;Shiozaki;Trends Biochem. Sci.,2004

5. Cell death regulation by the mammalian IAP antagonist Diablo/Smac;Verhagen;Apoptosis,2002

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