Replication competent retrovirus testing (RCR) in the National Gene Vector Biorepository: No evidence of RCR in 1,595 post-treatment peripheral blood samples obtained from 60 clinical trials

Author:

Cornetta KennethORCID,Yao Jing,House Kimberley,Duffy Lisa,Adusumilli Prasad S.,Beyer Rachel,Booth Claire,Brenner Malcolm,Curran Kevin,Grilley Bambi,Heslop Helen,Hinrichs Christian S.,Kaplan Rosandra N.,Kiem Hans-Peter,Kochenderfer James,Kohn Donald B.,Mailankody Sham,Norberg Scott M.,O'Cearbhaill Roisin E.,Pappas Jennifer,Park Jae,Ramos Carlos,Ribas Antonio,Rivière Isabelle,Rosenberg Steven A.,Sauter Craig,Shah Nirali N.,Slovin Susan F.,Thrasher Adrian,Williams David A.,Lin Tsai-Yu

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology,Genetics,Molecular Biology,Molecular Medicine

Reference20 articles.

1. Analysis of retroviral packaging lines for generationof replication-competent virus;Muenchau;Virology,1990

2. Replication-defective chimeric helper proviruses and factors affecting generation of competent virus: expression of Moloney Leukemia Virus structural genes via the metallothionein promoter;Bosselman;Mol. Cell. Biol.,1987

3. Infection of human cells with murine amphotropic replication-competent retroviruses;Cornetta;Hum. Gene Ther.,1993

4. Helper virus induction T cell lymphoma in nonhuman primates after retroviral mediated gene transfer;Donahue;J. Exp. Med.,1992

5. Meeting FDA guidance recommendations for replication competent virus and insertional oncogenesis testing;Cornetta;Mol. Ther. Methods Clin. Dev.,2022

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