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High Glucose Induces Mesangial Cell Apoptosis through miR-15b-5p and Promotes Diabetic Nephropathy by Extracellular Vesicle Delivery

  • Published:2020-03 Issue:3 Volume:28 Page:963-974
  • ISSN:1525-0016
  • Container-title:Molecular Therapy
  • language:en
  • Short-container-title:Molecular Therapy

Author:

Tsai Yi-Chun,Kuo Mei-Chuan,Hung Wei-Wen,Wu Ling-Yu,Wu Ping-Hsun,Chang Wei-An,Kuo Po-Lin,Hsu Ya-Ling

Funder

Kaohsiung Medical University Chung-Ho Memorial Hospital

Ministry of Science and Technology, Taiwan

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology,Genetics,Molecular Biology,Molecular Medicine

Reference29 articles.

1. Global estimates of the prevalence of diabetes for 2010 and 2030;Shaw;Diabetes Res. Clin. Pract.,2010

2. Cellular and molecular mechanisms of diabetic glomerulopathy;Gnudi;Nephrol. Dial. Transplant.,2012

3. Contractile properties of cultured glomerular mesangial cells;Kreisberg;Am. J. Physiol.,1985

4. Glucose enhances mesangial cell apoptosis;Khera;Lab. Invest.,2006

5. Glomerular cell replication and cell loss through apoptosis in experimental diabetes mellitus;Pesce;Nephron,2002
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