Genome-wide Mapping of Off-Target Events in Single-Stranded Oligodeoxynucleotide-Mediated Gene Repair Experiments

Author:

Radecke Sarah,Schwarz Klaus,Radecke Frank

Funder

Institute for Clinical Transfusion Medicine and Immunogenetics Ulm

German Red Cross Blood Service

EU

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology,Genetics,Molecular Biology,Molecular Medicine

Reference50 articles.

1. Site-directed mutagenesis: generation of an extracistronic mutation in bacteriophage Q beta RNA;Flavell;J. Mol. Biol.,1974

2. Gene therapy: progress and predictions;Collins;Proc. Biol. Sci.,2015

3. Gene therapy returns to centre stage;Naldini;Nature,2015

4. Targeted gene repair in mammalian cells using chimeric RNA/DNA oligonucleotides and modified single-stranded vectors;Parekh-Olmedo;Sci. STKE,2001

5. Unmodified oligodeoxynucleotides require single-strandedness to induce targeted repair of a chromosomal EGFP gene;Radecke;J. Gene Med.,2004

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