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Self-Transducible Bimodal PDX1-FOXP3 Protein Lifts Insulin Secretion and Curbs Autoimmunity, Boosting Tregs in Type 1 Diabetic Mice

  • Published:2018-01 Issue:1 Volume:26 Page:184-198
  • ISSN:1525-0016
  • Container-title:Molecular Therapy
  • language:en
  • Short-container-title:Molecular Therapy

Author:

Amatya Christina,Radichev Ilian A.,Ellefson Jacob,Williams Mark,Savinov Alexei Y.

Funder

Sanford Research

Juvenile Diabetes Research Foundation

NIH

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology,Genetics,Molecular Biology,Molecular Medicine

Reference83 articles.

1. Pancreatic islets under attack: cellular and molecular effectors;Pearl-Yafe;Curr. Pharm. Des.,2007

2. Type I diabetes mellitus. A chronic autoimmune disease;Eisenbarth;N. Engl. J. Med.,1986

3. The NOD mouse: a model of immune dysregulation;Anderson;Annu. Rev. Immunol.,2005

4. Islet pathology and the pathogenesis of type 1 and type 2 diabetes mellitus revisited;Klöppel;Surv. Synth. Pathol. Res.,1985

5. Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities;Cnop;Diabetes,2005

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