Synthesis and COX-2 inhibitory properties of N-phenyl- and N-benzyl-substituted amides of 2-(4-methylsulfonylphenyl)cyclopent-1-ene-1-carboxylic acid and of their pyrazole, thiophene and isoxazole analogs

Author:

Rapposelli Simona,Lapucci Annalina,Minutolo Filippo,Orlandini Elisabetta,Ortore Gabriella,Pinza Mario,Balsamo Aldo

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmaceutical Science

Reference30 articles.

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3. Structure of COX-1 and COX-2 enzymes and their interaction with inhibitors;Bakhle;Drug Today,1999

4. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain;Seibert;Proc. Natl. Acad. Sci. USA,1994

5. Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues;O’Neill;FEBS Lett,1993

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