Synthesis and Evaluation of Efavirenz (SustivaTM) Analogues as HIV-1 Reverse Transcriptase Inhibitors: Replacement of the Cyclopropylacetylene Side Chain

Author:

Cocuzza Anthony J.,Chidester Dennis R.,Cordova Beverly C.,Jeffrey Susan,Parsons Rodney L.,Bacheler Lee T.,Erickson-Viitanen Susan,Trainor George L.,Ko Soo S.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference9 articles.

1. L-743, 726 (DMP-266): a novel, highly potent nonnucleoside inhibitor of the human immunodeficiency virus type 1 reverse transcriptase

2. Panel on Clinical Practices for the Treatment of HIV Infection. Guidelines for the Use of Antiretroviral Agents in HIV-Infected Adults and Adolescents. 28 January 2000; http://www.hivatis.org

3. Bacheler, L.; Weislow, O.; Snyder, S.; Hanna, G.; D'Aquila, R.; the SUSTIVA Resistance Study Team. Abstract, presented at the 38th Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, CA, 24–27 September 1998.

4. Synthesis and evaluation of analogs of Efavirenz (SUSTIVATM) as HIV-1 reverse transcriptase inhibitors

5. Synthesis and evaluation of benzoxazinones as HIV-1 reverse transcriptase inhibitors. Analogs of Efavirenz (SUSTIVATM)

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