Novel 4-piperidinopyridine inhibitors of oxidosqualene cyclase-lanosterol synthase derived by consideration of inhibitor pKa-Reference-Cited by-同舟云学术

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Novel 4-piperidinopyridine inhibitors of oxidosqualene cyclase-lanosterol synthase derived by consideration of inhibitor pKa

Published:2001-08 Issue:16 Volume:11 Page:2213-2216
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Brown George R,Foubister Alan J,Johnson Michael C,Newcombe Nicholas J,Waterson David,Wells Stuart L

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference8 articles.

1. Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia

2. Inhalation of levomepromazine in severe acute asthma

3. A Novel Series of 4-Piperidinopyridine and 4-Piperidinopyrimidine Inhibitors of 2,3-Oxidosqualene Cyclase−Lanosterol Synthase

4. Inhibitors of squalene biosynthesis and metabolism

Cited by 13 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Selective Substitution Reactions at the Phosphorus Atom of 1,3-Dienyl Phosphonates;Chemistry Letters;2023-08-05

2. Modulation of lanosterol synthase drives 24,25-epoxysterol synthesis and oligodendrocyte formation;Cell Chemical Biology;2021-06

3. Design strategies of oxidosqualene cyclase inhibitors: Targeting the sterol biosynthetic pathway;The Journal of Steroid Biochemistry and Molecular Biology;2017-07

4. Arylpiperidines as a new class of oxidosqualene cyclase inhibitors;European Journal of Medicinal Chemistry;2016-02

5. Aminopropylindenes derived from Grundmann's ketone as a novel chemotype of oxidosqualene cyclase inhibitors;European Journal of Medicinal Chemistry;2013-05

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