A novel class of highly potent, selective, and non-peptidic inhibitor of ras farnesyltransferase (FTase)-Reference-Cited by-同舟云学术

A novel class of highly potent, selective, and non-peptidic inhibitor of ras farnesyltransferase (FTase)

Published:2001-12 Issue:23 Volume:11 Page:3069-3072
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Lee Hyunil,Lee Jinho,Lee Sangkyun,Shin Youseung,Jung Wonhee,Kim Jong-Hyun,Park Kiwon,Kim Kwihwa,Cho Heung Soo,Ro Seonggu,Lee Sunhwa,Jeong ShinWu,Choi Taesaeng,Chung Hyun-Ho,Koh Jong Sung

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference22 articles.

1. p21ras is modified by a farnesyl isoprenoid.

2. ras GENES

3. Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity.

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