Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics-Reference-Cited by-同舟云学术

Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics

Published:2002-12 Issue:24 Volume:12 Page:3537-3541
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Fraley Mark E.,Rubino Robert S.,Hoffman William F.,Hambaugh Scott R.,Arrington Kenneth L.,Hungate Randall W.,Bilodeau Mark T.,Tebben Andrew J.,Rutledge Ruth Z.,Kendall Richard L.,McFall Rosemary C.,Huckle William R.,Coll Kathleen E.,Thomas Kenneth A.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference25 articles.

1. Synthesis and Secretion of Vascular Permeability Factor/Vascular Endothelial Growth Factor by Human Retinal Pigment Epithelial Cells

2. The angiogenic pathway ?vascular endothelial growth factor/flk-1(KDR)-receptor? in rheumatoid arthritis and osteoarthritis

3. The role of VEGF and thrombospondins in skin angiogenesis

4. Angiogenesis in cancer and other diseases

5. Angiogenesis in cancer, vascular, rheumatoid and other disease

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