N-acyl-3-alkylidenyl- and 3-alkyl azeitidin-2-ones: a new class of monocyclic β-lactam antibacterial agents 2. Synthesis and structure-activity relationships of heteroatom substituted 3-isopropylidene and 3-isopropyl analogs-Reference-Cited by-同舟云学术

N-acyl-3-alkylidenyl- and 3-alkyl azeitidin-2-ones: a new class of monocyclic β-lactam antibacterial agents 2. Synthesis and structure-activity relationships of heteroatom substituted 3-isopropylidene and 3-isopropyl analogs

Published:1993-11 Issue:11 Volume:3 Page:2241-2246
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Brickner Steven J.,Gaikema Jeffrey J.,Greenfield Laura J.,Zurenko Gary E.,Manninen Peter R.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference14 articles.

1. N-Acyl 3-alkylidenyl- and 3-alkyl azetidin-2-ones: A new class of monocyclic .BETA.-lactam antibacterial agents. 1. Structure-activity relationships of 3-isopropylidene and 3-isopropyl analogs.

2. Monocyclic β-lactam inhibitors of human leukocyte elastase

3. Sequence of active site peptides from the penicillin-sensitive D-alanine carboxypeptidase of Bacillus subtilis. Mechanism of penicillin action and sequence homology to beta-lactamases.

4. An application of the PD(O)-catalyzed cyclocarbonylation of primary2-bromoallylamines to the synthesis of E- and Z-3-(hydroxyisopropylidene) azetidin-2-ones, useful precursors to a new class of monocyclic β-lactam antibiotics

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