Derivatives of 1-hydroxy-3-aminopyrrolidin-2-one (HA-966). Partial agonists at the glycine site of the NMDA receptor-Reference-Cited by-同舟云学术

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Derivatives of 1-hydroxy-3-aminopyrrolidin-2-one (HA-966). Partial agonists at the glycine site of the NMDA receptor

Published:1993-01 Issue:1 Volume:3 Page:71-76
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Leeson Paul D.,Williams Brian J.,Rowley Michael,Moore Kevin W.,Baker Raymond,Kemp John A.,Priestley Tony,Foster Alan C.,Donald Angus E.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference27 articles.

1. The behavioural effects of MK-801: a comparison with antagonists acting non-competitively and competitively at the NMDA receptor

2. In Vivo Distribution of CGS-19755 Within Brain in a Model of Focal Cerebral Ischemia

3. HA-966 antagonizes N-methyl-D-aspartate receptors through a selective interaction with the glycine modulatory site

4. Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative.

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