Molecular design, synthesis, and structure–Activity relationships leading to the potent and selective p56lck inhibitor BMS-243117-Reference-Cited by-同舟云学术

Molecular design, synthesis, and structure–Activity relationships leading to the potent and selective p56lck inhibitor BMS-243117

Published:2003-07 Issue:13 Volume:13 Page:2145-2149
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Das Jagabandhu,Lin James,Moquin Robert V.,Shen Zhongqi,Spergel Steven H.,Wityak John,Doweyko Arthur M.,DeFex Henry F.,Fang Qiong,Pang Suhong,Pitt Sidney,Shen Ding Ren,Schieven Gary L.,Barrish Joel C.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference19 articles.

1. Profound block in thymocyte development in mice lacking p56lck

2. A dominant-negative transgene defines a role for p56lck in thymopoiesis.

3. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

4. The Role of Protein Tyrosine Kinases and Protein Tyrosine Phosphatases in T Cell Antigen Receptor Signal Transduction

5. Signal transduction by lymphocyte antigen receptors

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