Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: Effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice-Reference-Cited by-同舟云学术

Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: Effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice

Published:1998-10 Issue:19 Volume:8 Page:2797-2802
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Holladay Mark W.,Bai Hao,Li Yihong,Lin Nan-Horng,Daanen Jerome F.,Ryther Keith B.,Wasicak James T.,Kincaid John F.,He Yun,Hettinger Anne-Marie,Huang Peggy,Anderson David J.,Bannon Anthony W.,Buckley Michael J.,Campbell Jeffrey E.,Donnelly-Roberts Diana L.,Gunther Karen L.,Kim David J.B.,Kuntzweiler Theresa A.,Sullivan James P.,Decker Michael W.,Arneric Stephen P.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference15 articles.

1. Identification and Initial Structure−Activity Relationships of (R)-5-(2-Azetidinylmethoxy)-2-chloropyridine (ABT-594), a Potent, Orally Active, Non-Opiate Analgesic Agent Acting via Neuronal Nicotinic Acetylcholine Receptors

2. Broad-Spectrum, Non-Opioid Analgesic Activity by Selective Modulation of Neuronal Nicotinic Acetylcholine Receptors

3. Antinociceptive effects of the novel neuronal nicotinic acetylcholine receptor agonist, ABT-594, in mice

4. Novel 3-Pyridyl Ethers with Subnanomolar Affinity for Central Neuronal Nicotinic Acetylcholine Receptors

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