Author:
Lagu Bharat,Tian Dake,Chiu George,Nagarathnam Dhanapalan,Fang James,Shen Quanrong,Forray Carlos,Ransom Richard W.,Chang Raymond S.L.,Vyas Kamlesh P.,Zhang Kanyin,Gluchowski Charles
Subject
Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry
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4. The in vitro metabolism was studied using suspensions of freshly isolated hepatocytes and microsomal preparations from rat, dog and humans. The compounds were incubated with liver microsomal protein and NADPH for 60 min. Following centrifugation, the supernatant was dried, reconstituted with 30% acetonitrile and analyzed by electrospray LC–MS/MS.
5. Dihydropyrimidine calcium channel blockers: 2-heterosubstituted 4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic acid esters as potent mimics of dihydropyridines
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