Author:
Brancale Andrea,McGuigan Christopher,Andrei Graciela,Snoeck Robert,De Clercq Erik,Balzarini Jan
Subject
Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry
Reference9 articles.
1. Potent and Selective Inhibition of Varicella-Zoster Virus (VZV) by Nucleoside Analogues with an Unusual Bicyclic Base
2. Nucleic acid related compounds. 39. Efficient conversion of 5-iodo to 5-alkynyl and derived 5-substituted uracil bases and nucleosides
3. New fluorinating reagents. Dialkylaminosulfur fluorides
4. Preparation of 3b: To a stirred solution 10-undecyn-1-ol (2.0 g, 11.88 mmol) in dichloromethane (10 mL) was added thionyl chloride (20.7 mmol, 2.46 g, 1.5 mL) and pyridine (11.88 mmol, 0.94 g, 0.96 mL). The reaction was then left stirred for 1 h at room temperature. The solvent was evaporated, water was added to the reaction mixture and then extracted with dichloromethane. The organic layer was dried on MgSO4, filtered and the solvent removed in vacuo, yielding to the product 2b as a colourless oil in quantitative yield.
5. A stereospecific route to aziridinomitosanes: the synthesis of novel mitomycin congeners
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