Author:
Young Jonathan R.,Huang Song X.,Chen Irene,Walsh Thomas F.,DeVita Robert J.,Wyvratt Matthew J.,Goulet Mark T.,Ren Ning,Lo Jane,Yang Yi Tien,Yudkovitz Joel B.,Cheng Kang,Smith Roy G.
Subject
Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry
Reference13 articles.
1. (a) DeVita, R. J.; Hollings, D. D.; Goulet, M. T.; Wyvratt, M. J., Jr.; Fisher, M. H.; Lo, J.; Yang, Y. T.; Cheng, K.; Smith, R. G. Bioorg. Med. Chem. Lett. 1999, 9, 2615. (b) DeVita, R. J.; Goulet, M. T.; Wyvratt, M. J., Jr.; Fisher, M. H.; Lo, J.; Yang, Y. T.; Cheng, K.; Smith, R. G. Bioorg. Med. Chem. Lett. 1999, 9, 2621. (c) Walsh, T. F.; Toupence, R. B.; Young, J. R.; Huang, S. X.; DeVita, R. J.; Goulet, M. T.; Wyvratt, Jr., M. J.; Fisher, M. H.; Lo, J.-L.; Cui, J.; Ren, N.; Yudkovitz, J. B.; Yang, Y. T.; Cheng, K.; Smith, R. G. Bioorg. Med. Chem. Lett. 2000, 10, 443.
2. For the preparation of the indanephenylacetic acid and the 3,4,5-trimethylphenylacetic acid, the syntheses began with the phenols which were processed according to the following 4-step sequence.
3. Antimalarial phenathrene amino alcohols. 1. Fluorine-containing 3- and 6-substituted 9-phenanthrenemethanols
4. Racemic N-BOC-2(2′-hydroxyethyl)-piperidine 8 was prepared by protection of the free-amine using standard conditions (BOC2O, NEt3, CH2Cl2). The S-enantiomer of 8 was prepared by Arndt–Eistert homologation of N-BOC (S)-pipecolic acid.
5. Kalir, A.; Mualem, R. Synthesis 1987, 514.
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