SAR of 4-hydroxypiperidine and hydroxyalkyl substituted heterocycles as novel p38 map kinase inhibitors

Author:

Revesz Laszlo,Di Padova Franco E,Buhl Thomas,Feifel Roland,Gram Hermann,Hiestand Peter,Manning Ute,Zimmerlin Alfred G

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference25 articles.

1. p38 MAPK signalling cascades in inflammatory disease

2. Novel Homologues of CSBP/p38 MAP Kinase: Activation, Substrate Specificity and Sensitivity to Inhibition by Pyridinyl Imidazoles

3. Lee, J. C.; Blumenthal, M. J.; Laydon, J. T.; Tan, K. B.; DeWitt, D. L. 7th International Conference of the Inflammatory Research Association; Poconos, PA, 1994. Lin, W. W.; Chen, B. C. Br. J. Pharmacol. 1999, 126, 1419.

4. Badger, A. M.; Bradbeer, J. N.; Votta, B.; Lee, J. C.; Adams, J. L.; Griswold, D. E. J. Pharmacol. Exp. Ther. 1996, 279, 1453. Lee, J. C.; Kassis, S.; Kumar, S.; Badger, A.; Adams, Jerry L. Pharmacol. Ther. 1999, 82, 389.

5. 1: GP054086. Fitzi, K. DE 2221546, 1972; Chem. Abstr. 1972, 78, 58428.

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